A nanostructured electrode for a polymer electrolyte fuel cell, a manufacturing method thereof, and a fuel cell including the nanostructured electrode are provided. The nanostructured electrode includes: a three-dimensional nanostructure including a nanoporous aerogel and an ionomer surrounding the surface of the aerogel; and a catalyst dispersed in the three-dimensional nanostructure. The electrode can obtain excellent current density and power density even with a relatively small amount of catalyst by having improved catalyst performance due to nanostructuring of an ionomer, uniform catalyst dispersion and increased catalyst utilization ratio, can also obtain a price reduction effect through a decrease in the amount of catalyst used, and is excellent in the mass transfer efficiency and low humidification performance.