Technical solutions are described for inter-controller communication in a protocol agnostic manner. For example, a method includes generating, by a sending controller, a protocol agnostic data frame including a pattern identifier, a rolling counter, a message identifier, a signal group, a cyclic redundancy check (CRC), a complement of the pattern identifier, and a complement of the rolling counter. The method further includes sending, by the sending controller, the protocol agnostic data frame to a first receiving controller that uses a first communication protocol, and sending, by the sending controller, the protocol agnostic data frame to a second receiving controller that uses a second communication protocol.