A connector connection indicator is mounted in a Luer male connector, or in a Luer female connector, to indicate proper mating of the two Luer connectors. The connection indicator may be or include a light source, a sound producing device (e.g., buzzer), a switch, a tactile connection indicator or an electronic chip. The electronic chip may be interposed between two conductive elements that are mounted in the Luer female connector. When the two Luer connectors are properly engaged, the electronic chip is powered via two electrical terminals. While the electronic chip is powered up it communicates with an external system via two electrical terminals. The external system interprets the communication with the electronic chip as an indication to proper engagement of the two Luer connectors. Some of the connection indicators may be mounted on a circuit board that is embedded in a void in the Luer male connector.