The present disclosure involves a hardware-supported 3D-stacked NVM data compression method and system, involving setting a first identifier to mark a compression state of written-back data, the method at least comprising steps of: dividing the written-back data into a plurality of sub-blocks and acquiring a plurality of first output results through OR operations among the sub-blocks, respectively, or acquiring a plurality of second output results through exclusive OR operations among the sub-blocks, and determining a compression strategy for the written-back data based on the first output results or the second output results; and setting a second identifier to mark a storing means of the written-back data so that the second identifier is in pair with the first identifier, and configuring a storage strategy for the written-back data that includes at least rotating the second identifier.