Systems and methods for multi-resource scheduling are disclosed and described. An example apparatus includes a scheduler engine configured to enable clinical system(s) to operate with the scheduler engine in an analytical mode and an operating mode. When in the analytical mode, the scheduler engine is to dynamically calculate one or more binding constraints on the one or more clinical systems for scheduling. When in the operating mode, the scheduler engine is to manage and output a schedule for the one or more clinical systems based on the one or more binding constraints calculated in the analytical mode. The example scheduler engine is to dynamically switch between the analytical mode and the operating mode based at least in part on a probabilistic determination of delay associated with the schedule.