In the present invention, by providing an apparatus for generating a hologram based on human visual system modeling, including a lens configured to focus light emitted from a three-dimensional (3D) object, a sensor configured to detect the light, an object information obtaining unit configured to obtain object information of the 3D object based on information of the lens and a confusion circle size threshold value corresponding to information of the sensor, and a hologram image generating unit configured to generate a hologram image for the 3D object based on the object information, it is possible to provide a method of generating a hologram based on a human visual system capable of generating image information of a three-dimensional object faster and capable of generating a higher-quality hologram image.