Example methods, apparatus, systems and articles of manufacture (e.g., physical storage media) to change a time sensitive networking schedule implemented by a softswitch are disclosed. Example apparatus disclosed herein to change a time sensitive networking schedule implemented by a first softswitch on a compute node include a network node configurator to deploy a second softswitch on the compute node based on a first configuration specification associated with the first softswitch, configure the second softswitch to implement an updated time sensitive networking schedule different from the time sensitive networking schedule implemented by the first softswitch, and replace the first softswitch with the second softswitch in response to a determination that a first set of constraints is met for simulated network traffic processed by the second softswitch based on the updated time sensitive networking schedule. Disclosed example apparatus also include a simulator to apply the simulated network traffic to the second softswitch.