Invention Grant
- Patent Title: Benzoylglycine derivatives and methods of making and using same
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Application No.: US16096611Application Date: 2017-04-25
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Publication No.: US11034649B2Publication Date: 2021-06-15
- Inventor: Pei Zhou , Eric J. Toone , Robert A. Nicholas , Ramesh Gopalaswamy , Xiaofei Liang , Frank Navas, III
- Applicant: Duke University , The University of North Carolina at Chapel Hill
- Applicant Address: US NC Durham; US NC Chapel Hill
- Assignee: Duke University,The University of North Carolina at Chapel Hill
- Current Assignee: Duke University,The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Durham; US NC Chapel Hill
- Agency: Polsinelli PC
- Agent Michelle L. McMullen
- International Application: PCT/US2017/029429 WO 20170425
- International Announcement: WO2017/189586 WO 20171102
- Main IPC: C07C259/06
- IPC: C07C259/06 ; C07D265/30 ; C07D295/10 ; C07D213/64 ; C07D277/40 ; C07D335/02 ; C07D203/18 ; C07C259/18 ; C07C311/06 ; C07C317/44 ; C07C317/18 ; C07C237/34 ; C07D207/327 ; C07D263/16 ; C07D295/155 ; C07D203/08 ; C07D309/10 ; C07D309/04 ; C07H15/203 ; A61P31/04
Abstract:
Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R1, R2, R3, R4, R5, R6, R7, R11, R12, R13, R14, R15, R16, R17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.
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