Invention Grant
- Patent Title: Peptide mimotopes of the CD3 T-cell co-receptor epsilon chain and uses thereof
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Application No.: US15741902Application Date: 2015-07-14
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Publication No.: US11046745B2Publication Date: 2021-06-29
- Inventor: Ugur Sahin , Laura Marie Kring , Markus Fiedler , Matin Daneschdar , Hans-Ulrich Schmoldt , Ulf Reimer , Karsten Schnatbaum
- Applicant: BioNTech SE , TRON—Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-Universitat Mainz gGmbH , JPT Peptides Technologies GmbH
- Applicant Address: DE Mainz; DE Mainz; DE Berlin
- Assignee: BioNTech SE,TRON—Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-Universitat Mainz gGmbH,JPT Peptides Technologies GmbH
- Current Assignee: BioNTech SE,TRON—Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-Universitat Mainz gGmbH,JPT Peptides Technologies GmbH
- Current Assignee Address: DE Mainz; DE Mainz; DE Berlin
- Agency: Sheppard Mullin Richter & Hampton LLP
- International Application: PCT/EP2015/066071 WO 20150714
- International Announcement: WO2017/008844 WO 20170119
- Main IPC: A61K38/08
- IPC: A61K38/08 ; C07K7/06 ; G01N33/566 ; G01N33/68 ; C07K14/725 ; A61K47/64 ; A61K47/66 ; C12N15/62 ; A61K38/00
Abstract:
The present invention provides molecules that mimic antigenic determinants of the CD3 (cluster of differentiation 3) T-cell co-receptor epsilon chain (CD3ε). These molecules compete with CD3ε for binding to a CD3ε binding domain. e.g. a CD3ε binding domain of an antibody, and are capable of detecting antibodies against CD3ε. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Additionally, they may serve as tools for anti-CD3ε antibody purification and the detection of anti-CD3ε antibodies in biological samples.
Public/Granted literature
- US20190070248A1 PEPTIDE MIMOTOPES OF THE CD3 T-CELL CO-RECEPTOR EPSILON CHAIN AND USES THEREOF Public/Granted day:2019-03-07
Information query
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