- 专利标题: CD70 binding molecules and methods of use thereof
-
申请号: US15896619申请日: 2018-02-14
-
公开(公告)号: US11046775B2公开(公告)日: 2021-06-29
- 发明人: Ruben Alvarez Rodriguez , Armen Mardiros
- 申请人: KITE PHARMA, INC.
- 申请人地址: US CA Santa Monica
- 专利权人: KITE PHARMA, INC.
- 当前专利权人: KITE PHARMA, INC.
- 当前专利权人地址: US CA Santa Monica
- 代理机构: Barnes & Thornburg LLP
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; C07K14/705 ; C07K14/725 ; C12N5/0783 ; A61P35/00
摘要:
The disclosure provides anti-CD70 antibodies, antigen binding fragments thereof, chimeric antigen receptors (CARs) and engineered T cell receptors (TCRs) comprising an antigen binding molecule that specifically binds to CD70, polynucleotides encoding the same, and in vitro cells comprising the same. The polynucleotides, polypeptides, and in vitro cells described herein can be used in an engineered TCR and/or CAR T cell therapy for the treatment of a patient suffering from a cancer. In one embodiment, the polynucleotides, polypeptides, and in vitro cells described herein can be used for the treatment of multiple myeloma.
公开/授权文献
- US20180230224A1 CD70 BINDING MOLECULES AND METHODS OF USE THEREOF 公开/授权日:2018-08-16
信息查询