专利检索 ap:("KITE PHARMA, INC.") AND inv:"Armen Mardiros" 第 1 页

1.

发明授权
CD70 binding molecules and methods of use thereof 有权

公开(公告)号：US11046775B2

公开(公告)日：2021-06-29

申请号：US15896619

申请日：2018-02-14

申请人： KITE PHARMA, INC.

发明人： Ruben Alvarez Rodriguez , Armen Mardiros

IPC分类号： C07K16/28 , C07K14/705 , C07K14/725 , C12N5/0783 , A61P35/00

摘要： The disclosure provides anti-CD70 antibodies, antigen binding fragments thereof, chimeric antigen receptors (CARs) and engineered T cell receptors (TCRs) comprising an antigen binding molecule that specifically binds to CD70, polynucleotides encoding the same, and in vitro cells comprising the same. The polynucleotides, polypeptides, and in vitro cells described herein can be used in an engineered TCR and/or CAR T cell therapy for the treatment of a patient suffering from a cancer. In one embodiment, the polynucleotides, polypeptides, and in vitro cells described herein can be used for the treatment of multiple myeloma.