A method for integrating a processing-in-sensor unit and an in-memory computing includes the following steps. A providing step is performed to transmit the first command signal and the initial data to the in-memory computing unit. A converting step is performed to drive the first command signal and the initial data to convert to a second command signal and a plurality of input data through a synchronizing module. A fetching step is performed to drive a frame difference module to receive the input data to fetch a plurality of difference data. A slicing step is performed to drive a bit-slicing module to receive the difference data and slice each of the difference data into a plurality of bit slices. A controlling step is performed to encode the difference address into a control signal, and the in-memory computing unit accesses each of the bit slices according to the control signal.