- 专利标题: Antibodies targeting CDH19 for melanoma
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申请号: US15878047申请日: 2018-01-23
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公开(公告)号: US11053311B2公开(公告)日: 2021-07-06
- 发明人: Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , M. Shawn Jeffries , Chadwick Terence King , Brian Mingtung Chan
- 申请人: AMGEN INC.
- 申请人地址: US CA Thousand Oaks
- 专利权人: AMGEN INC.
- 当前专利权人: AMGEN INC.
- 当前专利权人地址: US CA Thousand Oaks
- 代理机构: Marshall, Gerstein & Borun LLP
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; C07K16/28 ; A61K47/68 ; C07K16/30
摘要:
The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.
公开/授权文献
- US20180208654A1 Antibodies Targeting CDH19 for Melanoma 公开/授权日:2018-07-26
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