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    ANTIBODIES TARGETING CDH19 FOR MELANOMA
    7.
    发明申请
    ANTIBODIES TARGETING CDH19 FOR MELANOMA 有权

    公开(公告)号：US20220127354A1

    公开(公告)日：2022-04-28

    申请号：US17326717

    申请日：2021-05-21

    申请人： AMGEN INC.

    发明人： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan

    IPC分类号： C07K16/28 ,  A61K47/68 ,  C07K16/30

    摘要： The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.

    Antibodies targeting CDH19 for melanoma
    8.
    发明授权
    Antibodies targeting CDH19 for melanoma 有权

    公开(公告)号：US11053311B2

    公开(公告)日：2021-07-06

    申请号：US15878047

    申请日：2018-01-23

    申请人： AMGEN INC.

    发明人： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan

    IPC分类号： A61K39/00 ,  C07K16/28 ,  A61K47/68 ,  C07K16/30

    摘要： The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.

    ANTIBODIES TARGETING CDH19 FOR MELANOMA
    10.
    发明申请
    ANTIBODIES TARGETING CDH19 FOR MELANOMA 有权
    针对MELANOMA的针对CDH19的抗体

    公开(公告)号：US20150322151A1

    公开(公告)日：2015-11-12

    申请号：US14762053

    申请日：2014-01-27

    申请人： AMGEN INC.

    发明人： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan

    IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K47/48

    CPC分类号： C07K16/28 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6865 ,  A61K2039/505 ,  C07K16/3053 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92

    摘要： The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.

    摘要翻译： 本公开提供了人抗体或其抗原结合片段或包含能够结合目标细胞表面上的人CDH19的人结合结构域或其抗原结合片段的抗体构建体。 本公开涉及编码抗体构建体中包含的抗体或其抗原结合片段的核酸序列，包含核酸序列的载体和用该载体转化或转染的宿主细胞。 此外，本公开涉及制备本公开的抗体构建体的方法，医疗用途或使用抗体构建体的治疗方法和包含抗体或其抗原结合片段或抗体构建体的试剂盒。