- 专利标题: Imidazolyl tricyclic enones as antioxidant inflammation modulators
-
申请号: US15548909申请日: 2016-02-12
-
公开(公告)号: US11059792B2公开(公告)日: 2021-07-13
- 发明人: Xin Jiang , Bradley William Caprathe , Chitase Lee , Gary Bolton , Christopher F. Bender , Melean Visnick
- 申请人: REATA PHARMACEUTICALS, INC.
- 申请人地址: US TX Irving
- 专利权人: REATA PHARMACEUTICALS, INC.
- 当前专利权人: REATA PHARMACEUTICALS, INC.
- 当前专利权人地址: US TX Irving
- 代理机构: Parker Highlander PLLC
- 国际申请: PCT/US2016/017769 WO 20160212
- 国际公布: WO2016/130927 WO 20160818
- 主分类号: C07D235/08
- IPC分类号: C07D235/08 ; A61P29/00 ; C07D235/02 ; C07D235/10 ; C07D235/12 ; C07D401/04 ; C07D403/04 ; C07D403/10 ; C07D403/14 ; C07C235/02
摘要:
Disclosed herein are compounds of the formula: (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders associated with inflammation and cancer.