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公开(公告)号：US11993574B2
公开(公告)日：2024-05-28
申请号：US17251295
申请日：2019-06-17
发明人： Xin Jiang , Melean Visnick , Christopher F. Bender , Gary Bolton , Bradley Caprathe , Chitase Lee , Brian Kornberg , Patrick O'Brien , Martha R. Hotema
IPC分类号： C07D231/54 , C07D235/02 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： C07D231/54 , C07D235/02 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.
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公开(公告)号：US11406648B2
公开(公告)日：2022-08-09
申请号：US17135128
申请日：2020-12-28
发明人： Xin Jiang , Christopher F. Bender , Melean Visnick
IPC分类号： C07D271/06 , C07D271/10 , A61K31/58 , C07J63/00
摘要： Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.
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公开(公告)号：US20220135534A1
公开(公告)日：2022-05-05
申请号：US17577456
申请日：2022-01-18
发明人： Xin JIANG , Christopher F. BENDER , Melean VISNICK , Martha R. HOTEMA , Zachary S. SHELDON , Chitase LEE , Bradley William CAPRATHE , Gary BOLTON , Brian KORNBERG
IPC分类号： C07D401/04 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/14
摘要： Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.
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公开(公告)号：US11292781B2
公开(公告)日：2022-04-05
申请号：US16468054
申请日：2017-12-16
发明人： Xin Jiang , Christopher F. Bender , Melean Visnick , Martha R. Hotema , Zachary S. Sheldon , Chitase Lee , Bradley William Caprathe , Gary Bolton , Brian Kornberg
IPC分类号： A61P37/00 , C07D401/14 , C07D401/04 , C07D401/12 , C07D413/14 , C07D413/04 , C07D239/70 , C07D221/04 , C07D403/04 , C07D417/14 , A61P35/00 , A61P29/00
摘要： Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.
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公开(公告)号：US20210292281A1
公开(公告)日：2021-09-23
申请号：US17251295
申请日：2019-06-17
发明人： Xin JIANG , Melean VISNICK , Christopher F. BENDER , Gary BOLTON , Bradley CAPRATHE , Chitase LEE , Brian KORNBERG , Patrick O'BRIEN , Martha R. HOTEMA
IPC分类号： C07D231/54 , C07D401/04 , C07D409/04 , C07D405/04 , C07D401/10 , C07D413/10 , C07D401/14 , C07D403/14 , C07D403/10 , C07D403/04 , C07D417/04 , C07D417/14 , C07D413/14 , C07D235/02
摘要： Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.
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公开(公告)号：US11091430B2
公开(公告)日：2021-08-17
申请号：US16786429
申请日：2020-02-10
发明人： Eric Anderson , Xin Jiang , Melean Visnick
IPC分类号： C07C255/47 , C07J63/00 , C07C275/34 , C07C271/24 , C07C275/26 , C07C311/09 , C07D261/08 , C07D307/20 , C07D487/08 , C07C311/07 , C07D209/56 , C07D211/44 , C07D231/12 , C07D295/195
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
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公开(公告)号：US10898499B2
公开(公告)日：2021-01-26
申请号：US16527171
申请日：2019-07-31
发明人： Xin Jiang , Christopher F. Bender , Melean Visnick
IPC分类号： C07J63/00 , C07D271/06 , A61K31/58 , C07D271/10
摘要： Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.
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公开(公告)号：US20200347088A1
公开(公告)日：2020-11-05
申请号：US16894461
申请日：2020-06-05
IPC分类号： C07H15/207 , A61P3/10 , C07H1/06 , A61P25/02 , A61K31/7048
摘要： Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline or D-proline, their pharmaceutical compositions, processes of manufacture, and methods of use for treating neurodegenerative disorders such as diabetic peripheral neuropathy.
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9.发明申请公开(公告)号：US20200239410A1
公开(公告)日：2020-07-30
申请号：US16786429
申请日：2020-02-10
发明人： Eric ANDERSON , Xin JIANG , Melean VISNICK
IPC分类号： C07C255/47 , C07C275/34 , C07J63/00 , C07C271/24 , C07D261/08 , C07C311/09 , C07D211/44 , C07D307/20 , C07C275/26 , C07C311/07 , C07D487/08 , C07D209/56 , C07D295/195 , C07D231/12
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
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10.发明授权公开(公告)号：US09512094B2
公开(公告)日：2016-12-06
申请号：US14566827
申请日：2014-12-11
发明人： Xin Jiang , Christopher F. Bender , Melean Visnick
IPC分类号： C07D271/10 , C07D271/06 , C07J63/00
CPC分类号： A61K31/58 , C07D271/06 , C07D271/10 , C07J63/008
摘要： Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.
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