- 专利标题: Antitumor drug delivery formulation
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申请号: US15777498申请日: 2016-11-18
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公开(公告)号: US11066665B2公开(公告)日: 2021-07-20
- 发明人: Yutaka Kondo , Keisuke Katsushima , Kazunori Kataoka , Kanjiro Miyata , Hyun Jin Kim
- 申请人: PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY , THE UNIVERSITY OF TOKYO
- 申请人地址: JP Nagoya; JP Tokyo
- 专利权人: PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY,THE UNIVERSITY OF TOKYO
- 当前专利权人: PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY,THE UNIVERSITY OF TOKYO
- 当前专利权人地址: JP Nagoya; JP Tokyo
- 代理机构: Brinks Gilson & Lione
- 优先权: JPJP2015-226895 20151119
- 国际申请: PCT/JP2016/084328 WO 20161118
- 国际公布: WO2017/086467 WO 20170526
- 主分类号: C12N15/11
- IPC分类号: C12N15/11 ; C12N15/113 ; A61K31/713 ; A61K35/76 ; A61K31/7088 ; C12N15/00 ; A61K9/00 ; A61K47/60 ; A61P35/00 ; A61K9/107
摘要:
This invention provides an antitumor drug delivery formulation for treating a subject having a tumor more highly expressing a TUG1 gene than normal tissues or preventing the subject from tumor metastasis, comprising a polymeric micelle comprising a nucleic acid that suppresses high expression of the TUG1 gene as an active ingredient, wherein the polymeric micelle comprises a block copolymer having a cationic poly(amino acid) segment and a hydrophilic polymer chain segment and the nucleic acid, and wherein the nucleic acid is bound to a cationic group of the cationic poly(amino acid) segment to form a complex and/or the nucleic acid is incorporated in the micelle or attached into the micelle; and the polymeric micelle accumulates in the tumor.
公开/授权文献
- US20180334674A1 ANTITUMOR DRUG DELIVERY FORMULATION 公开/授权日:2018-11-22
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