This disclosure relates to performing cellular communication in unlicensed spectrum in a manner that accounts for the possible existence of hidden nodes by opportunistically introducing the use of RTS and CTS messages. A listen-before-talk procedure may be performed to determine whether a wireless medium is available. When the listen-before-talk procedure is complete, an amount of time until a next possible start time for communicating in the cellular communication system according to a timing synchronization scheme for the cellular communication system may be determined. The wireless medium may be occupied until the next possible start time for communicating in the cellular communication system in a manner selected based at least in part on the amount of time until the next possible start time for communicating in the cellular communication system. Cellular communication may be performed on the wireless medium at the next possible start time for communicating in the cellular communication system.