- 专利标题： Methods of treating and preventing Staphylococcus aureus infections and associated conditions
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申请号： US16860716申请日： 2020-04-28
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公开(公告)号： US11078258B2公开(公告)日： 2021-08-03
- 发明人: Victor J. Torres , Francis Alonzo, III
- 申请人： New York University
- 申请人地址： US NY New York
- 专利权人： New York University
- 当前专利权人： New York University
- 当前专利权人地址： US NY New York
- 代理机构： Troutman Pepper Hamilton Sanders LLP (Rochester)
- 主分类号： A61K39/085
- IPC分类号： A61K39/085 ; C07K16/12 ; G01N33/50 ; G01N33/569 ; A61K39/40 ; A61K31/7088 ; A61K31/724 ; A61K38/16 ; A61K39/00
摘要：
The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
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