The present disclosure relates to a touch display substrate. The touch display substrate includes a substrate, data lines, a common electrode layer, first lead-wire lines, second lead-wire lines, a pixel electrode layer, and compensation electrode lines. Data lines are distributed at intervals on one side of the substrate along a row direction, and include first data lines and second data lines. The second lead-wires are connected to the second electrode blocks in columns. The pixel electrode layer includes a plurality of pixel electrodes distributed in an array, and two adjacent columns of the pixel electrodes are disposed on both sides of one of the data lines. The compensation electrode lines are disposed on the same layer as the pixel electrodes, and orthographic projections of the second data lines and the compensation electrode lines on the substrate overlap in one-to-one correspondence.