- 专利标题: Optimized PNE-based chimeric receptor T cell switches and uses thereof
-
申请号: US15566680申请日: 2016-04-15
-
公开(公告)号: US11091546B2公开(公告)日: 2021-08-17
- 发明人: Travis Young , David T. Rodgers , Ian Hardy , Chanhyuk Kim , Peter G. Schultz , Eric Hampton , Eduardo Laborda , Leonard Presta
- 申请人: The Scripps Research Institute
- 申请人地址: US CA La Jolla
- 专利权人: The Scripps Research Institute
- 当前专利权人: The Scripps Research Institute
- 当前专利权人地址: US CA La Jolla
- 代理商 Hugh Wang; Thomas Fitting
- 国际申请: PCT/US2016/027997 WO 20160415
- 国际公布: WO2016/168773 WO 20161020
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; A61K35/17 ; C07K16/18 ; C07K16/32 ; A61P35/00 ; C07K14/39 ; A61K39/00
摘要:
Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.
公开/授权文献
信息查询