公开(公告)号：US10800828B2

公开(公告)日：2020-10-13

申请号：US15561274

申请日：2016-03-28

申请人： The Scripps Research Institute

发明人： Travis Young ,  Chanhyuk Kim ,  Peter G. Schultz

IPC分类号： C07K14/705 ,  C07K7/08 ,  C07K14/47 ,  A61K38/00 ,  C12N9/12 ,  A61K48/00 ,  C07K14/725 ,  A61P35/00 ,  C07K14/195 ,  C07K14/32 ,  C07K14/78 ,  C12N5/0783 ,  C12N9/22

摘要： Disclosed herein are switchable chimeric receptors, switchable chimeric receptor effector cells and chimeric receptor effector cell switches. The switchable chimeric receptor-ECs are generally T cells. The chimeric receptors have non-antibody extracellular domains that recognize a chimeric receptor binding partner on the chimeric receptor-EC switch or target cell. The chimeric receptor-ECs and switches may be used for the treatment of a disease or condition in a subject in need thereof.

公开(公告)号：US20140287464A1

公开(公告)日：2014-09-25

申请号：US14165199

申请日：2014-01-27

申请人： The Scripps Research Institute

发明人： Travis Young ,  Peter G. Schultz

IPC分类号： C12N15/81 ,  A61K47/48

CPC分类号： C12N15/815 ,  C07K2319/00 ,  C07K2319/55 ,  C12N9/93 ,  C12P21/02

摘要： The invention provides orthogonal translation systems for the production of polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris. Methods for producing polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris are also provided.

摘要翻译： 本发明提供用于在甲基营养酵母如巴斯德毕赤酵母中生产包含非天然氨基酸的多肽的正交翻译系统。 还提供了在甲基营养酵母如巴斯德毕赤酵母中生产包含非天然氨基酸的多肽的方法。

公开(公告)号：US20180104354A1

公开(公告)日：2018-04-19

申请号：US15644657

申请日：2017-07-07

申请人： The California Institute for Biomedical Research ,  The Scripps Research Institute

发明人： Chanhyuk Kim ,  Travis Young ,  Yu Cao ,  Jennifer Ma ,  Minsoo Kim ,  Stephanie A. Pinkerton ,  Peter G. Schultz

IPC分类号： C07K16/28 ,  A61K31/4188 ,  A61K39/385 ,  C07K16/44 ,  C07K16/40 ,  C07K16/32 ,  A61K31/352 ,  A61K49/00 ,  A61K39/395

CPC分类号： A61K47/6849 ,  A61K31/352 ,  A61K31/4188 ,  A61K39/385 ,  A61K39/3955 ,  A61K47/6835 ,  A61K49/0041 ,  A61K49/0058 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2878 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/32 ,  C07K16/40 ,  C07K16/44 ,  C07K2317/522 ,  C07K2317/567 ,  C07K2317/622

摘要： Disclosed herein are switches for regulating the activity of a chimeric antigen receptor effector cells (CAR-ECs). The switches generally comprise a chimeric antigen receptor-interacting domain (CAR-ID) and a target interacting domain (TID). The switch may further comprise a linker. Further disclosed herein are methods of using the switches for the treatment of one or more conditions or diseases in a subject in need thereof.

公开(公告)号：US09732349B2

公开(公告)日：2017-08-15

申请号：US14165199

申请日：2014-01-27

申请人： The Scripps Research Institute

发明人： Travis Young ,  Peter G. Schultz

IPC分类号： C07K16/00 ,  C12N15/81 ,  C12N9/00 ,  C12P21/02 ,  A61K47/48

CPC分类号： C12N15/815 ,  C07K2319/00 ,  C07K2319/55 ,  C12N9/93 ,  C12P21/02

摘要： The invention provides orthogonal translation systems for the production of polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris. Methods for producing polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris are also provided.

公开(公告)号：US11421033B2

公开(公告)日：2022-08-23

申请号：US16663239

申请日：2019-10-24

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： Feng Wang ,  Matthew S. Tremblay ,  Travis Young ,  Nicole Alvarez ,  Yan Liu ,  Juanjuan Du ,  Peter G. Schultz

IPC分类号： C07K16/46 ,  C07K16/28 ,  C07K14/62 ,  A61P3/10

摘要： Disclosed herein are immunoglobulin fusion proteins comprising an insulin therapeutic peptide and an immunoglobulin region that targets the insulin therapeutic peptide to the liver of an individual in need thereof. Further disclosed herein are compositions comprising the immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject, for example, diabetes and diabetes related conditions.

公开(公告)号：US20220152110A1

公开(公告)日：2022-05-19

申请号：US17441653

申请日：2020-03-23

申请人： The Regents of the University of California ,  The Scripps Research Institute

发明人： Dan S. Kaufman ,  Xiao-Hua Li ,  Eduardo Laborda ,  Travis Young

IPC分类号： A61K35/17 ,  C07K14/725 ,  C07K16/30 ,  C07K14/705 ,  C07K16/28 ,  A61P35/00

摘要： Engineered natural killer cells with switchable chimeric antigen receptor, methods of manufacture, pharmaceutical compositions, and methods of use in treating cancer and viral infection.

公开(公告)号：US11091546B2

公开(公告)日：2021-08-17

申请号：US15566680

申请日：2016-04-15

申请人： The Scripps Research Institute

发明人： Travis Young ,  David T. Rodgers ,  Ian Hardy ,  Chanhyuk Kim ,  Peter G. Schultz ,  Eric Hampton ,  Eduardo Laborda ,  Leonard Presta

IPC分类号： C07K16/28 ,  A61K35/17 ,  C07K16/18 ,  C07K16/32 ,  A61P35/00 ,  C07K14/39 ,  A61K39/00

摘要： Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.

公开(公告)号：US10391155B2

公开(公告)日：2019-08-27

申请号：US15448477

申请日：2017-03-02

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： Travis Young ,  Chanhyuk Kim ,  Peter G. Schultz

IPC分类号： A61K39/00 ,  C07K16/28 ,  A61K39/395 ,  C12N5/0783 ,  C07K14/00 ,  C07K14/395 ,  C07K16/00 ,  C12N5/10 ,  C07K19/00 ,  A61K38/00

摘要： Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.

公开(公告)号：US09109022B2

公开(公告)日：2015-08-18

申请号：US14065111

申请日：2013-10-28

申请人： The Scripps Research Institute

发明人： Travis Young ,  Peter G. Schultz

IPC分类号： C07K14/765 ,  C07K16/00 ,  A61K38/00 ,  C07K16/18 ,  C07K19/00 ,  C12N15/81 ,  C07K14/78 ,  C12N15/62 ,  C12P21/02

CPC分类号： C07K16/18 ,  C07K14/765 ,  C07K14/78 ,  C07K19/00 ,  C12N15/62 ,  C12N15/815 ,  C12P21/02

摘要： Provided are methods of making carrier polypeptide that include incorporating a first unnatural amino acid into a carrier polypeptide variant, incorporating a second unnatural amino acid into a target polypeptide variant, and reacting the first and second unnatural amino acids to produce the conjugate. Conjugates produced using the provided methods are also provided. In addition, orthogonal translation systems in methylotrophic yeast and methods of using these systems to produce carrier and target polypeptide variants comprising unnatural amino acids are provided.

摘要翻译： 提供了制备载体多肽的方法，其包括将第一非天然氨基酸掺入载体多肽变体中，将第二非天然氨基酸掺入靶多肽变体中，并使第一和第二非天然氨基酸反应以产生缀合物。 还提供了使用提供的方法生产的缀合物。 此外，提供了甲基营养酵母中的正交翻译系统以及使用这些系统产生包含非天然氨基酸的载体和靶多肽变体的方法。

公开(公告)号：US20140170704A1

公开(公告)日：2014-06-19

申请号：US14065111

申请日：2013-10-28

申请人： The Scripps Research Institute

发明人： Travis Young ,  Peter G. Schultz

IPC分类号： C07K16/18 ,  C07K14/765

CPC分类号： C07K16/18 ,  C07K14/765 ,  C07K14/78 ,  C07K19/00 ,  C12N15/62 ,  C12N15/815 ,  C12P21/02

摘要： Provided are methods of making carrier polypeptide that include incorporating a first unnatural amino acid into a carrier polypeptide variant, incorporating a second unnatural amino acid into a target polypeptide variant, and reacting the first and second unnatural amino acids to produce the conjugate. Conjugates produced using the provided methods are also provided. In addition, orthogonal translation systems in methylotrophic yeast and methods of using these systems to produce carrier and target polypeptide variants comprising unnatural amino acids are provided.

摘要翻译： 提供了制备载体多肽的方法，其包括将第一非天然氨基酸掺入载体多肽变体中，将第二非天然氨基酸掺入靶多肽变体中，并使第一和第二非天然氨基酸反应以产生缀合物。 还提供了使用提供的方法生产的缀合物。 此外，提供了甲基营养酵母中的正交翻译系统以及使用这些系统产生包含非天然氨基酸的载体和靶多肽变体的方法。