- 专利标题： GPR84 receptor antagonist and use thereof
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申请号： US16490837申请日： 2018-02-28
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公开(公告)号： US11098071B2公开(公告)日： 2021-08-24
- 发明人: Fajun Nan , Xin Xie , Linhai Chen , Qing Zhang , Yufeng Xiao , Hui Yang
- 申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 申请人地址： CN Shanghai
- 专利权人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 当前专利权人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 当前专利权人地址： CN Shanghai
- 代理机构： Kilpatrick Townsend & Stockton LLP
- 优先权： CN201710128201.3 20170306
- 国际申请： PCT/CN2018/077584 WO 20180228
- 国际公布： WO2018/161831 WO 20180913
- 主分类号： C07F9/09
- IPC分类号： C07F9/09 ; C07F9/655 ; C07F9/6553 ; C07F9/6561
摘要：
The present invention relates to a GPR84 receptor antagonist and use thereof. The GPR84 receptor antagonist of the present invention has a structure as represented by formula (I), the definitions of R1, R2, R3, R4, L1, L2, L3, L4, L5, L6, Y, Z, and rings A, B, C, and D are as described in the description and claims. The GPR84 receptor antagonist of the present invention can competitively inhibit the activation of the receptor caused by an agonist of GPR84, and can be used in the preparation of a medicament for treating related diseases caused by high expression or high excitability of GPR84 receptor, the diseases including multiple sclerosis, inflammatory bowel disease, arthritis and the like.
公开/授权文献
- US20200010492A1 GPR84 RECEPTOR ANTAGONIST AND USE THEREOF 公开/授权日：2020-01-09