发明授权
- 专利标题： Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
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申请号： US16461902申请日： 2017-11-13
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公开(公告)号： US11104690B2公开(公告)日： 2021-08-31
- 发明人: Dong-Ming Shen , Thomas H. Graham , Wensheng Liu , Clare Tudge , Andreas Verras , Jinlong Jiang
- 申请人： Merck Sharp & Dohme Corp. , Dong-Ming Shen , Thomas H. Graham , Wensheng Liu , Clare Tudge , Andreas Verras , Jinlong Jiang
- 申请人地址： US NJ Rahway; US NJ Edison; US MA Quincy; US NJ Edison; US PA Wayne; US NY New York; US NJ Scotch Plains
- 专利权人： Merck Sharp & Dohme Corp.,Dong-Ming Shen,Thomas H. Graham,Wensheng Liu,Clare Tudge,Andreas Verras,Jinlong Jiang
- 当前专利权人： Merck Sharp & Dohme Corp.,Dong-Ming Shen,Thomas H. Graham,Wensheng Liu,Clare Tudge,Andreas Verras,Jinlong Jiang
- 当前专利权人地址： US NJ Rahway; US NJ Edison; US MA Quincy; US NJ Edison; US PA Wayne; US NY New York; US NJ Scotch Plains
- 代理商 Sarah L. Hooson; Catherine D. Fitch
- 国际申请： PCT/US2017/061223 WO 20171113
- 国际公布： WO2018/093696 WO 20180524
- 主分类号： C07D515/08
- IPC分类号： C07D515/08 ; C07D409/12 ; C07D401/12 ; C07D403/12 ; C07D231/56 ; C07D405/12 ; C07D487/04 ; C07D417/12 ; C07D413/12 ; C07D409/14
摘要：
The present invention relates to a compound represented by formula I′: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
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