公开(公告)号：US20190330239A1

公开(公告)日：2019-10-31

申请号：US16461902

申请日：2017-11-13

申请人： Dong-Ming Shen ,  Thomas H. Graham ,  Wensheng LIU ,  Clare TUDGE ,  Andreas VERRAS ,  Jinlong JIANG ,  Merck Sharp & Dohme Corp.

发明人： Dong-Ming Shen ,  Thomas H. Graham ,  Wensheng Liu ,  Clare Tudge ,  Andreas Verras ,  Jinlong Jiang

IPC分类号： C07D515/08 ,  C07D409/12 ,  C07D401/12 ,  C07D403/12 ,  C07D231/56 ,  C07D405/12 ,  C07D487/04 ,  C07D417/12 ,  C07D413/12 ,  C07D409/14

摘要： The present invention relates to a compound represented by formula I′: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.

公开(公告)号：US11104690B2

公开(公告)日：2021-08-31

申请号：US16461902

申请日：2017-11-13

申请人： Merck Sharp & Dohme Corp. ,  Dong-Ming Shen ,  Thomas H. Graham ,  Wensheng Liu ,  Clare Tudge ,  Andreas Verras ,  Jinlong Jiang

发明人： Dong-Ming Shen ,  Thomas H. Graham ,  Wensheng Liu ,  Clare Tudge ,  Andreas Verras ,  Jinlong Jiang

IPC分类号： C07D515/08 ,  C07D409/12 ,  C07D401/12 ,  C07D403/12 ,  C07D231/56 ,  C07D405/12 ,  C07D487/04 ,  C07D417/12 ,  C07D413/12 ,  C07D409/14

摘要： The present invention relates to a compound represented by formula I′: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.

公开(公告)号：US20190218223A1

公开(公告)日：2019-07-18

申请号：US16324596

申请日：2017-08-10

申请人： Jared N. CUMMING ,  Kevin D. DYKSTRA ,  Alan HRUZA ,  Derun LI ,  Hong LIU ,  Haiqun TANG ,  Brandon M. TAOKA ,  Andreas VERRAS ,  Shawn P. WALSH ,  Wen-Lian WU ,  Merck Sharp & Dohme Corp.

发明人： Jared N. Cumming ,  Kevin D. Dykstra ,  Alan Hruza ,  Derun Li ,  Hong Liu ,  Haiqun Tang ,  Brandon M. Taoka ,  Andreas Verras ,  Shawn P. Walsh ,  Wen-Lian Wu

IPC分类号： C07D487/04 ,  C07D519/00 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04 ,  A61P3/10

CPC分类号： C07D487/04 ,  A61P3/10 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

摘要： Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.

公开(公告)号：US20230008022A1

公开(公告)日：2023-01-12

申请号：US17295497

申请日：2019-11-25

申请人： Dane CLAUSEN ,  Ping CHEN ,  Xavier FRADERA ,  Liangqin GUO ,  Yongxin HAN ,  Shuwen HE ,  Xianhai HUANG ,  Joseph KOZLOWSKI ,  Guoqing LI ,  Theodore A. MARTINOT ,  Alexander PASTERNAK ,  Andreas VERRAS ,  Li XIAO ,  Wensheng YU ,  Rui ZHANG ,  Merck Sharp & Dohme Corp.

发明人： Dane Clausen ,  Ping Chen ,  Xavier Fradera ,  Liangqin Guo ,  Yongxin Han ,  Shuwen He ,  Xianhai Huang ,  Joseph Kozlowski ,  Guoqing Li ,  Theodore A. Martinot ,  Alexander Pasternak ,  Andreas Verras ,  Li Xiao ,  Feng Ye ,  Wensheng Yu ,  Rui Zhang

IPC分类号： C07D231/56 ,  C07D491/052 ,  C07D231/54 ,  A61K31/496 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  A61K31/5377 ,  C07D498/10 ,  C07D491/107 ,  C07D498/08 ,  C07D471/10 ,  C07D403/12 ,  C07D405/12 ,  C07D498/04 ,  C07D487/04 ,  C07D487/10 ,  A61K31/541 ,  C07D413/14

摘要： Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US10414774B2

公开(公告)日：2019-09-17

申请号：US16324596

申请日：2017-08-10

申请人： Merck Sharp & Dohme Corp. ,  Jared N. Cumming ,  Kevin D. Dykstra ,  Alan Hruza ,  Derun Li ,  Hong Liu ,  Haiqun Tang ,  Brandon M. Taoka ,  Andreas Verras ,  Shawn P. Walsh ,  Wen-Lian Wu

发明人： Jared N. Cumming ,  Kevin D. Dykstra ,  Alan Hruza ,  Derun Li ,  Hong Liu ,  Haiqun Tang ,  Brandon M. Taoka ,  Andreas Verras ,  Shawn P. Walsh ,  Wen-Lian Wu

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61P3/10 ,  C07D498/04 ,  C07D513/04 ,  C07D471/04

摘要： Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.

公开(公告)号：US20210330676A1

公开(公告)日：2021-10-28

申请号：US17268995

申请日：2019-08-16

申请人： Merck Sharp & Dohme Corp.

发明人： Dane Clausen ,  Xavier Fradera ,  Liangqin Guo ,  Yongxin Han ,  Shuwen He ,  Xianhai Huang ,  Joseph Kozlowski ,  Guoqing Li ,  Jongwon Lim ,  Theodore A. Martinot ,  Alexander Pasternak ,  Nunzio Sciammetta ,  Andreas Verras ,  Li Xiao ,  Wensheng Yu ,  Rui Zhang

IPC分类号： A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D401/06 ,  C07D413/14 ,  C07D451/06 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/454 ,  A61K31/46

摘要： Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US10414775B2

公开(公告)日：2019-09-17

申请号：US16324604

申请日：2017-08-10

申请人： Merck Sharp & Dohme Corp.

发明人： John P. Caldwell ,  Mary Ann Caplen ,  Jared N. Cumming ,  Kevin D. Dykstra ,  Alan Hruza ,  Claire Lankin ,  Derun Li ,  Hong Liu ,  Amy McCracken ,  Brian McKittrick ,  Ashwin Rao ,  Jayaram Tagat ,  Haiqun Tang ,  Brandon M. Taoka ,  Andreas Verras ,  Shawn P. Walsh ,  Wen-Lian Wu ,  Tianyuan Zhang

IPC分类号： C07D519/00 ,  C07D487/04 ,  C07D498/04

摘要： Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.

公开(公告)号：US20190218224A1

公开(公告)日：2019-07-18

申请号：US16324604

申请日：2017-08-10

申请人： Merck Sharp & Dohme Corp.

发明人： John P. Caldwell ,  Mary Ann Caplen ,  Jared N. Cumming ,  Kevin D. Dykstra ,  Alan Hruza ,  Claire Lankin ,  Derun Li ,  Hong Liu ,  Amy McCracken ,  Brian McKittrick ,  Ashwin Rao ,  Jayaram Tagat ,  Haiqun Tang ,  Brandon M. Taoka ,  Andreas Verras ,  Shawn P. Walsh ,  Wen-Lian Wu ,  Tianyuan Zhang

IPC分类号： C07D487/04 ,  C07D519/00 ,  C07D498/04

CPC分类号： C07D487/04 ,  C07D498/04 ,  C07D519/00

摘要： Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.

公开(公告)号：US08377953B2

公开(公告)日：2013-02-19

申请号：US12668435

申请日：2008-07-09

申请人： Peter Ackermann ,  Carla Bobbio ,  Camilla Corsi ,  Ann Monica McGinley ,  Andreas Verras ,  Ruud Titulaeu ,  Josef Ehrenfreund

发明人： Peter Ackermann ,  Carla Bobbio ,  Camilla Corsi ,  Ann Monica McGinley ,  Andreas Verras ,  Ruud Titulaeu ,  Josef Ehrenfreund

IPC分类号： A61K31/506 ,  A61K31/4439 ,  A01N43/56 ,  A01N43/80 ,  A01P3/00 ,  A61P31/10 ,  C07D401/06 ,  C07D417/06

CPC分类号： C07D417/06 ,  A01N43/56 ,  A01N43/80 ,  C07D401/06 ,  C07D417/14

摘要： The present invention relates to compounds of Formula (I) wherein R1, R2, R3 or R4 are as defined in claim 1 or a salt or N-oxide thereof and their use in methods for the control and/or prevention of fungal infection, particularly in plants. The compounds claimed are isothiazole and pyrazole derivatives.

摘要翻译： 本发明涉及其中R 1，R 2，R 3或R 4如权利要求1所定义的式（I）化合物或其盐或N-氧化物及其在控制和/或预防真菌感染的方法中的用途，特别是 在植物中。 所要求的化合物是异噻唑和吡唑衍生物。

公开(公告)号：US20110224241A1

公开(公告)日：2011-09-15

申请号：US12668435

申请日：2008-07-09

申请人： Peter Ackermann ,  Carla Bobbio ,  Camilla Corsi ,  Josef Ehrenfreund ,  Ann Monica McGinley ,  Andreas Verras ,  Ruud Titulaer

发明人： Peter Ackermann ,  Carla Bobbio ,  Camilla Corsi ,  Josef Ehrenfreund ,  Ann Monica McGinley ,  Andreas Verras ,  Ruud Titulaer

IPC分类号： A61K31/506 ,  C07D417/06 ,  A61K31/4439 ,  A01N43/80 ,  A61P31/10 ,  A01P3/00 ,  C07D401/06 ,  A01N43/56

CPC分类号： C07D417/06 ,  A01N43/56 ,  A01N43/80 ,  C07D401/06 ,  C07D417/14

摘要： The present invention relates to compounds of Formula (I) wherein R1, R2, R3 or R4 are as defined in claim 1 or a salt or N-oxide thereof and their use in methods for the control and/or prevention of fungal infection, particularly in plants. The compounds claimed are isothiazole and pyrazole derivatives.

摘要翻译： 本发明涉及其中R 1，R 2，R 3或R 4如权利要求1所定义的式（I）化合物或其盐或N-氧化物及其在控制和/或预防真菌感染的方法中的用途，特别是 在植物中。 所要求的化合物是异噻唑和吡唑衍生物。