Embodiments of the present invention allow more full characterization of a stenotic lesion by measuring both pressure drop across the stenotic lesion and the size of the vessel lumen adjacent the stenotic lesion, both with sensors delivered intravascularly to the stenotic lesion site. In preferred embodiments, the size (e.g., inner diameter, cross-sectional profile) of the vessel lumen adjacent the stenotic lesion can be measured via one or more intravascular ultrasound transducers. In preferred embodiments, the intravascular ultrasound transducer(s) can be delivered to the site of the stenotic lesion with the same delivery device that carries the pressure transducer(s).