The invention relates to a sealing and guiding system for a packaging machine having a processing zone and an activation zone adjacent each other. The system has a separating wall, for separating the processing zone from the activation zone; at least a movement actuating element, which develops from the activation zone to the processing zone, crossing the separating wall and that has a longitudinal developing axis; movement actuating means, arranged in the activation zone, for moving the movement actuating element at least along a first direction transverse to the respective axis.