Invention Grant
- Patent Title: Use of a small native peptide activator of SERCA pump for treatment of heart failure and other disorders characterized by cytosolic calcium overload
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Application No.: US16743831Application Date: 2020-01-15
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Publication No.: US11111278B2Publication Date: 2021-09-07
- Inventor: Eric N. Olson , Rhonda S. Bassel-Duby , Catherine A. Makarewich , Benjamin R. Nelson
- Applicant: The Board of Regents of the University of Texas System
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of the University of Texas System
- Current Assignee: The Board of Regents of the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Parker Highlander PLLC
- Main IPC: C07K14/47
- IPC: C07K14/47 ; A61K45/06 ; A61K38/17 ; A61K48/00
Abstract:
The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.
Information query
