公开(公告)号：US11111278B2

公开(公告)日：2021-09-07

申请号：US16743831

申请日：2020-01-15

Applicant: The Board of Regents of the University of Texas System

Inventor： Eric N. Olson ,  Rhonda S. Bassel-Duby ,  Catherine A. Makarewich ,  Benjamin R. Nelson

IPC: C07K14/47 ,  A61K45/06 ,  A61K38/17 ,  A61K48/00

Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.

公开(公告)号：US20170298107A1

公开(公告)日：2017-10-19

申请号：US15491057

申请日：2017-04-19

Applicant: The Board of Regents of the University of Texas System

Inventor： Eric N. Olson ,  Rhonda S. Bassel-Duby ,  Catherine A. Makarewich ,  Benjamin R. Nelson

IPC: C07K14/47 ,  A61K45/06 ,  A61K38/17

CPC classification number: C07K14/47 ,  A61K38/1709 ,  A61K45/06

Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.

公开(公告)号：US10570183B2

公开(公告)日：2020-02-25

申请号：US15491057

申请日：2017-04-19

Applicant: The Board of Regents of the University of Texas System

Inventor： Eric N. Olson ,  Rhonda S. Bassel-Duby ,  Catherine A. Makarewich ,  Benjamin R. Nelson

IPC: C07K14/47 ,  A61K38/17 ,  A61K45/06

Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.