Invention Grant
- Patent Title: Compositions and methods for acylating lactams
-
Application No.: US16055559Application Date: 2018-08-06
-
Publication No.: US11124503B2Publication Date: 2021-09-21
- Inventor: Brian M. Stoltz , Masaki Hayashi , Satoshi Hashimoto
- Applicant: California Institute of Technology
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasadena
- Agency: Foley Hoag LLP
- Agent Janine S. Ladislaw
- Main IPC: C07D409/06
- IPC: C07D409/06 ; C07D207/27 ; C07D207/273 ; C07D207/277
Abstract:
This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni catalyst. The methods comprise treating a lactam of formula (IIa): with a chiral Ni catalyst, an aryl nitrile, and an aryl halide to provide compounds of formula (Ia):
Public/Granted literature
- US20190077796A1 COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS Public/Granted day:2019-03-14
Information query
