公开(公告)号：US10040784B2

公开(公告)日：2018-08-07

申请号：US15454198

申请日：2017-03-09

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Masaki Hayashi ,  Satoshi Hashimoto

IPC: C07D409/06 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277

Abstract: This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni catalyst. The methods comprise treating a lactam with a chiral Ni catalyst, an aryl nitrile, and an aryl halide.

公开(公告)号：US11124503B2

公开(公告)日：2021-09-21

申请号：US16055559

申请日：2018-08-06

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Masaki Hayashi ,  Satoshi Hashimoto

IPC: C07D409/06 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277

Abstract: This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni catalyst. The methods comprise treating a lactam of formula (IIa): with a chiral Ni catalyst, an aryl nitrile, and an aryl halide to provide compounds of formula (Ia):

公开(公告)号：US20190077796A1

公开(公告)日：2019-03-14

申请号：US16055559

申请日：2018-08-06

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Masaki Hayashi ,  Satoshi Hashimoto

IPC: C07D409/06 ,  C07D207/277 ,  C07D207/27 ,  C07D207/273

Abstract: This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni catalyst. The methods comprise treating a lactam with a chiral Ni catalyst, an aryl nitrile, and an aryl halide.

公开(公告)号：US20170260172A1

公开(公告)日：2017-09-14

申请号：US15454198

申请日：2017-03-09

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Masaki Hayashi ,  Satoshi Hashimoto

IPC: C07D409/06 ,  C07D207/273 ,  C07D207/277 ,  C07D207/27

CPC classification number: C07D409/06 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277

Abstract: This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni catalyst. The methods comprise treating a lactam with a chiral Ni catalyst, an aryl nitrile, and an aryl halide.