Invention Grant
- Patent Title: Methods for overcoming glutamine deprivation during mammalian cell culture
-
Application No.: US15128732Application Date: 2015-03-24
-
Publication No.: US11124760B2Publication Date: 2021-09-21
- Inventor: William Yang , Yao-Ming Huang , Marty Sinacore , Thomas Ryll , Jiuyi Lu , Jaesun Lee , Kyngju Lee , Hyoung Taek Lim , Eunchong Yang
- Applicant: Biogen MA Inc. , Samsung Bioepis
- Applicant Address: US MA Cambridge; KR Incheon
- Assignee: Biogen MA Inc.,Samsung Bioepis
- Current Assignee: Biogen MA Inc.,Samsung Bioepis
- Current Assignee Address: US MA Cambridge; KR Incheon
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2015/022259 WO 20150324
- International Announcement: WO2015/148515 WO 20151001
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12P21/00
Abstract:
The present invention pertains to methods of producing polypeptide of interest in cell cultures lacking glutamine. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with nucleic acid synthesis precursors and/or corticosteroids.
Public/Granted literature
- US20170175075A1 Methods for Overcoming Glutamine Deprivation During Mammalian Cell Culture Public/Granted day:2017-06-22
Information query
