The present invention provides a method for an optimal scheduling decision of an air compressor group based on a simulation technology, which belongs to the technical field of information. The present invention uses expert experience to construct an air compressor energy consumption model sample set, and applies a least squares algorithm to learn relevant parameters of an air compressor energy consumption model; uses maximum energy conversion efficiency and minimum economic cost based on an equivalent electricity as target functions, and applies the simulation technology and a depth first tree search algorithm to solve a multi-target optimal scheduling model of the air compressor group; and finally uses a fuzzy logic theory to describe the preferences of decision makers, and introduces the decision maker preference information into interactive decision making, thereby assisting production staff to formulate safe, economical, efficient and environmentally friendly operation schemes to achieve an operation mode of maximum resource utilization of the air compressor group. The method also has wide application value in different industrial fields.