Methods and systems are provided for ultrasound multiplexing. In one embodiment, a system comprises: an ultrasound probe comprising a transducer array and a multiplexer, wherein for a first signal and a second signal originating at the transducer array, the multiplexer multiplexes a sum signal and a difference signal formed from the first and the second signals into a multiplexed signal; and a console coupled to the ultrasound probe via a cable, the console including a processor, wherein the console receives the multiplexed signal via the cable, and wherein the processor generates an image from the first signal and the second signal recovered from the multiplexed signal. In this way, the number of processing channels can be reduced, thereby enabling a smaller ultrasound device with less hardware, while also avoiding signal degradation from channel crosstalk and transmission variation.