- 专利标题: Sulfonylureas and related compounds and use of same
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申请号: US16535002申请日: 2019-08-07
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公开(公告)号: US11130731B2公开(公告)日: 2021-09-28
- 发明人: Luke O'Neill , Rebecca Coll , Matthew Cooper , Avril Robertson , Kate Schroder
- 申请人: THE UNIVERSITY OF QUEENSLAND , THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
- 申请人地址: AU Queensland; IE Dublin
- 专利权人: THE UNIVERSITY OF QUEENSLAND,THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
- 当前专利权人: THE UNIVERSITY OF QUEENSLAND,THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
- 当前专利权人地址: AU Queensland; IE Dublin
- 代理机构: Alston & Bird LLP
- 优先权: AU2015900507 20150216
- 主分类号: C07C311/56
- IPC分类号: C07C311/56 ; A61P5/00 ; C07D403/12 ; A61P37/00 ; A61P35/00 ; A61P3/00 ; A61P25/00 ; A61P1/00 ; C07D215/36 ; C07D401/12 ; C07D487/04 ; C07D493/04 ; A61P17/00 ; C07D213/71 ; C07D309/08 ; C07D311/18 ; C07D311/60 ; C07D217/22 ; C07D217/24 ; C07D495/04 ; C07D217/02 ; C07D221/18 ; C07D241/42 ; C07D307/68 ; C07D311/16 ; C07D333/52 ; C07D307/82 ; C07D307/64 ; C07D307/18 ; C07D277/36 ; C07D498/04 ; C07D207/38 ; C07D495/06 ; C07D271/12 ; C07D261/18 ; C07D249/12 ; C07D249/06 ; C07D249/04 ; C07D417/12 ; C07D241/44 ; C07D317/62 ; C07D231/18 ; C07D333/34 ; C07D333/62 ; C07C311/60 ; C07D405/12 ; C07D407/12 ; C07D413/12 ; C07D241/24 ; C07D235/02 ; C07D401/06
摘要:
The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.
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