A method for treating an intestine with an expandable scaffolding expanded within the intestine. After placing the expandable scaffolding at a target location, such as across a fistula, the first and second end portions of the expandable scaffolding are radially expanded such that the first and second end portions contact an inner surface of the intestine on opposing sides of the fistula, anchoring the first and second end portions to the intestine. Radially expanding the first and second end portions foreshortens the medial portion along the longitudinal axis such that the first and second end portions are drawn closer together along the longitudinal axis as the medial portion foreshortens to close the fistula.