There is provided an oriented wire electrostatic radiation protection system for a spacecraft. The system has a wire management system, and first and second wires coupled to the wire management system. A first wire orientation apparatus orients the first wire in a first wire direction toward, and in parallel alignment with, an approach path of approaching solar particles. A second wire orientation apparatus orients the second wire in a second wire direction opposite to the first wire direction. The system has a control system, and a power supply to charge the first wire to a positively-charged wire and to charge the second wire to a negatively-charged wire. When the approaching solar particles travel alongside the positively-charged wire toward the spacecraft, the positively-charged wire deflects the approaching solar particles away from the spacecraft, via electrostatic repulsion, and the positively-charged wire creates a radiation protection shielded region around the spacecraft.