Invention Grant
![Synthesis of labeled imidazo[1,2-A]pyrimidines](/docs/US/2021-10-05/US11136330B2/abs.jpg.600x600.jpg)
- Patent Title: Synthesis of labeled imidazo[1,2-A]pyrimidines
-
Application No.: US16869475Application Date: 2020-05-07
-
Publication No.: US11136330B2Publication Date: 2021-10-05
- Inventor: Kyle Bradley Pascual Clagg , Nicholas Andrew White , Haiming Zhang , Francis Gosselin , William Nack , Paul D. O'Shea
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Genentech, Inc.
- Agent Richard G. A. Bone
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07F9/24
![Synthesis of labeled imidazo[1,2-A]pyrimidines](/abs-image/US/2021/10/05/US11136330B2/abs.jpg.150x150.jpg)
Abstract:
A method of synthesizing comprising a step of making an imidazo-pyrimidine compound by coupling a first compound of formula (II) with a second compound of formula (III) Followed by a deprotection and tosylation step. The methods are able to produce an isotopically substituted molecule having upwards of 95% purity relative to non-isotopically substituted molecules.
The invention further comprises compounds of formula:
The invention further comprises compounds of formula:
Information query
