Invention Grant
- Patent Title: Controls for nucleic acid assays
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Application No.: US14424694Application Date: 2013-08-30
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Publication No.: US11136627B2Publication Date: 2021-10-05
- Inventor: Mikkel Noerholm , Susan Belzer , Charlotte Romain , Johan Karl Olov Skog , Leileata M. Russo , Wayne Comper
- Applicant: Exosome Diagnostics, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Exosome Diagnostics, Inc.
- Current Assignee: Exosome Diagnostics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Cooley LLP
- Agent Ivor R. Elrifi; Matthew Pavao
- International Application: PCT/US2013/057506 WO 20130830
- International Announcement: WO2014/036391 WO 20140306
- Main IPC: C12P19/34
- IPC: C12P19/34 ; C12Q1/6886 ; C12N7/00

Abstract:
The present invention features a method and kit for isolating microvesicles or extracting microvesicle nucleic acids from a biological sample by using a control particle. The present invention provides control particles that are viruses or virus-like particles, such as bacteriophages, that contain control nucleic acids that can be detected to assess the accuracy, reliability, and efficiency of the microvesicle isolation or nucleic acid extraction steps. The methods described herein may further comprise the analysis of the presence, absence, or level of at least one biomarker associated with a disease or medical condition for diagnosing, prognosing, or monitoring the disease or medical condition.
Public/Granted literature
- US20160312211A1 CONTROLS FOR NUCLEIC ACID ASSAYS Public/Granted day:2016-10-27
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