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公开(公告)号：US20160237422A1
公开(公告)日：2016-08-18
申请号：US15138746
申请日：2016-04-26
Applicant: Exosome Diagnostics, Inc.
Inventor： Wayne Comper , Leileata M. Russo , Johan Karl Olov Skog
CPC classification number: C12N15/1003 , C07H1/08 , C07H21/02 , C12N15/1006 , C12N15/101 , C12Q1/6806 , C12Q2527/127 , C12Q2563/161
Abstract: Methods for extracting high quality nucleic acids from a heterogenous collection of nucleic acid-containing materials from a biological sample are disclosed. The heterogenous collection of nucleic-acid containing materials may contain cells or microvesicles, or both. The extractions obtained by the methods described herein are characterized by high yield and high integrity, making the extracted nucleic acids useful for various applications in which high quality nucleic acid extractions are preferred, e.g., a diagnosis, prognosis, or therapy evaluation for a medical condition.
Abstract translation: 公开了从生物样品的含有核酸的材料的异质收集中提取高质量核酸的方法。 含有核酸的材料的异质收集可能含有细胞或微泡，或两者。 通过本文描述的方法获得的提取物的特征在于高产率和高完整性，使得提取的核酸可用于优先选择高质量核酸提取的各种应用，例如用于医疗状况的诊断，预后或治疗评估 。
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公开(公告)号：US20160075788A1
公开(公告)日：2016-03-17
申请号：US14768275
申请日：2014-02-14
Applicant: EXOSOME DIAGNOSTICS, INC.
Inventor： Johan Karl Olov Skog , Emily Berghoff , Lori LoGuidice
IPC: C07K16/28 , G01N33/574 , C12N15/113 , C12Q1/68 , C07K14/71 , A61K47/48
CPC classification number: C07K16/2863 , A61K47/6849 , C07K14/485 , C07K14/71 , C07K2317/76 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/57492 , G01N2333/71 , G01N2800/52
Abstract: The present invention features a novel EGFR variant, EGFRvVI, and methods for detecting the novel EGFR variant. The novel EGFR variant is preferentially expressed in some cancers. Methods for detecting EGFRvVI may aid in the diagnosis, prognosis, and therapeutic assessment of a subject.
Abstract translation: 本发明的特征在于一种新的EGFR变体，EGFRvVI和用于检测新型EGFR变体的方法。 新型EGFR变体优先在一些癌症中表达。 检测EGFRvVI的方法可能有助于对受试者的诊断，预后和治疗评估。
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公开(公告)号：US12258587B2
公开(公告)日：2025-03-25
申请号：US17295287
申请日：2019-11-20
Applicant: Exosome Diagnostics, Inc.
Inventor： Georg Stoll , Daniel Enderle , Mikkel Noerholm , Johan Karl Olov Skog
IPC: C12N15/10 , C12N7/00 , C12Q1/6806 , C12Q1/6851 , C12Q1/70
Abstract: The present disclosure provides compositions, methods and kits for internal controls of microvesicle isolations. The compositions, methods and kits can comprise enveloped viruses, including, but not limited to, inactive mouse hepatitis virus (MHV).
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公开(公告)号：US11407991B2
公开(公告)日：2022-08-09
申请号：US15138746
申请日：2016-04-26
Applicant: Exosome Diagnostics, Inc.
Inventor： Wayne Comper , Leileata M. Russo , Johan Karl Olov Skog
Abstract: Methods for extracting high quality nucleic acids from a heterogenous collection of nucleic acid-containing materials from a biological sample are disclosed. The heterogenous collection of nucleic-acid containing materials may contain cells or microvesicles, or both. The extractions obtained by the methods described herein are characterized by high yield and high integrity, making the extracted nucleic acids useful for various applications in which high quality nucleic acid extractions are preferred, e.g., a diagnosis, prognosis, or therapy evaluation for a medical condition.
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5.发明授权公开(公告)号：US10988755B2
公开(公告)日：2021-04-27
申请号：US14877531
申请日：2015-10-07
Applicant: Exosome Diagnostics, Inc.
Inventor： Johan Karl Olov Skog , Leileata M. Russo
IPC: C12N15/10
Abstract: A method for extracting nucleic acids from a biological sample by isolating nucleic acid-containing particles from the biological sample by one or more centrifugation procedures, performing one or more steps to mitigate adverse factors that prevent or might prevent high quality nucleic acid extraction, and extracting nucleic acids from the isolated particles. The centrifugation procedures are performed at a speed not exceeding about 200,000 g. The extracted nucleic acids contain both 18S and 28S rRNA.
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Patent Agency Ranking
公开(公告)号：US11214833B2
公开(公告)日：2022-01-04
申请号：US16098500
申请日：2017-05-05
Inventor： Johan Karl Olov Skog , Jamil Azzi
IPC: C12Q1/68 , C12P19/34 , C12Q1/6876 , C12Q1/686
Abstract: The invention relates generally to the use of microvesicle RNA signatures for diagnosis, predicting, and/or to monitor treatment efficacy, including patients who are candidates for renal transplant and/or who have received a renal transplant.
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公开(公告)号：US11136627B2
公开(公告)日：2021-10-05
申请号：US14424694
申请日：2013-08-30
Applicant: Exosome Diagnostics, Inc.
Inventor： Mikkel Noerholm , Susan Belzer , Charlotte Romain , Johan Karl Olov Skog , Leileata M. Russo , Wayne Comper
IPC: C12P19/34 , C12Q1/6886 , C12N7/00
Abstract: The present invention features a method and kit for isolating microvesicles or extracting microvesicle nucleic acids from a biological sample by using a control particle. The present invention provides control particles that are viruses or virus-like particles, such as bacteriophages, that contain control nucleic acids that can be detected to assess the accuracy, reliability, and efficiency of the microvesicle isolation or nucleic acid extraction steps. The methods described herein may further comprise the analysis of the presence, absence, or level of at least one biomarker associated with a disease or medical condition for diagnosing, prognosing, or monitoring the disease or medical condition.
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公开(公告)号：US20150038335A1
公开(公告)日：2015-02-05
申请号：US14357475
申请日：2012-11-12
Applicant: Exosome Diagnostics, Inc.
Inventor： Johan Karl Olov Skog , Leileata Russo
CPC classification number: C12Q1/6806 , C12N15/1003 , C12N15/1017 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention is directed to methods of isolating particles, such as nucleic acid-containing particles or microvesicles, from a biological sample and extracting nucleic acids therefrom, wherein the biological sample is cerebrospinal fluid. The present invention further provides methods for aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker associated with a disease or medical condition thereof.
Abstract translation: 本发明涉及从生物样品中分离出颗粒如含核酸颗粒或微泡，并从其中提取核酸的方法，其中生物样品是脑脊液。 本发明还提供了通过检测与疾病或其医学状况相关的生物标志物来帮助诊断，预后，监测和评估受试者中的疾病或其他医学状况的方法。
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公开(公告)号：US11899024B2
公开(公告)日：2024-02-13
申请号：US16629000
申请日：2018-07-12
Applicant: Exosome Diagnostics, Inc.
Inventor： Mia Sher , Erez Eitan , Christine Coticchia , Johan Karl Olov Skog , Robert Kitchen , Seth Yu
IPC: G01N33/68 , G01N33/537 , C12N15/10
CPC classification number: G01N33/6896 , C12N15/1013 , G01N33/537 , G01N2333/705 , G01N2800/28
Abstract: The invention relates generally to a process for isolating subpopulations of EVs to identify biomarkers useful identifying, determining the progression of, and/or prognosing a disease, including a neurological disease. More particularly, the present invention relates to detection technology of various exosomal biomarkers including proteins, protein modifications, sugars, RNA, DNA, lipids, and metabolites, and combinations thereof.
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公开(公告)号：US11427864B2
公开(公告)日：2022-08-30
申请号：US16463820
申请日：2017-11-17
Applicant: Exosome Diagnostics, Inc.
Inventor： Johan Karl Olov Skog , Elena Castellanos-Rizaldos , Vasisht Tadigotla , Dominik Grimm , Xuan Zhang , Wei Yu
IPC: C12P19/34 , C12Q1/6851 , C12Q1/6886
Abstract: The present invention relates generally to methods and kits for detecting one or more biomarkers, such as an Epidermal Growth Factor Receptor (EGFR) mutation, e.g., T790M mutation, L858R mutation, one or more exon19 insertions and/or one or more exon19 deletions in the EGFR gene, in a biological sample to aid in diagnosis, prognosis, monitoring, or therapy selection for a disease such as, for example, cancer. The methods and kits are useful in aiding in diagnosis, prognosis, monitoring, or therapy selection for lung cancer, e.g., non-small cell lung cancer (NSCLC).
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