![Process for the preparation of 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds](/docs/US/2021-10-12/US11142534B2/abs.jpg.600x600.jpg)
- 专利标题： Process for the preparation of 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds
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申请号： US16476165申请日： 2018-01-04
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公开(公告)号： US11142534B2公开(公告)日： 2021-10-12
- 发明人: Junli Chen , Manuel Konrath , Roland Meier , Yan Ren , Xuemei Wang , Jing Xiong , Jianhua Yu
- 申请人： Hoffmann-La Roche Inc.
- 申请人地址： US NJ Little Falls
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Little Falls
- 代理机构： Genentech, Inc.
- 代理商 Richard G. A. Bone
- 优先权： WOPCT/CN2017/070437 20170106,WOPCT/CN2017/112149 20171121
- 国际申请： PCT/EP2018/050159 WO 20180104
- 国际公布： WO2018/127525 WO 20180712
- 主分类号： C07D513/04
- IPC分类号： C07D513/04
![Process for the preparation of 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds](/abs-image/US/2021/10/12/US11142534B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to a process for synthesizing a compound of formula (I), R1 is H or C1-6alkyl; R2 is H or hydroxy; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.
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