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![Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5.6.8.8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid](/abs-image/US/2019/01/10/US20190010155A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190010155A1
公开(公告)日：2019-01-10
申请号：US15999701
申请日：2018-08-20
发明人： Junli Chen
IPC分类号： C07D487/04
摘要： The present invention relates to a process for synthesizing a compound of formula (I), R1 is phenyl, which is unsubstituted or substituted with one, two or three substituents independently selected from halogen and C1-6alkyl; R2 is C1-6alkyl; R3 is —CxH2x—; x is 1, 2, 3, 4, 5, 6 or 7; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.
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![Process for the preparation of N-[(3-aminooxetan-3-yl) methyl]-2-(1,1-dioxo-3,5-dihydro-1,4-benzothiazepin-4-yl)-6-methyl-quinazolin-4-amine](/abs-image/US/2019/04/09/US10253022B2/abs.jpg.150x150.jpg)
公开(公告)号：US10253022B2
公开(公告)日：2019-04-09
申请号：US15988570
申请日：2018-05-24
发明人： Junli Chen , Yi Ren , Jin She , Lin Wang , Jianhua Yu , Guocai Zhang
IPC分类号： C07D417/14 , C07D305/06 , C07D305/08
摘要： The present invention relates to a novel process for the preparation of a compound of the formula (I): and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.
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![Process for the preparation of 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds](/abs-image/US/2021/10/12/US11142534B2/abs.jpg.150x150.jpg)
公开(公告)号：US11142534B2
公开(公告)日：2021-10-12
申请号：US16476165
申请日：2018-01-04
发明人： Junli Chen , Manuel Konrath , Roland Meier , Yan Ren , Xuemei Wang , Jing Xiong , Jianhua Yu
IPC分类号： C07D513/04
摘要： The present invention relates to a process for synthesizing a compound of formula (I), R1 is H or C1-6alkyl; R2 is H or hydroxy; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.
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公开(公告)号：US20170204107A1
公开(公告)日：2017-07-20
申请号：US15479701
申请日：2017-04-05
发明人： Johannes Aebi , Kurt E. Amrein , Junli Chen , Benoit Hornsperger , Bernd Kuhn , Yongfu Liu , Dongbo Li , Hans Peter Maerki , Rainer E. Martin , Alexander Mayweg , Xuefei Tan , Jun Wu , Jianhua Yu
IPC分类号： C07D487/10 , C07D471/10
CPC分类号： C07D487/10 , A61K9/2054 , A61K9/2059 , C07D471/10 , C07D519/00
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R5, A1, A2, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.
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![Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid](/abs-image/US/2021/02/23/US10927116B2/abs.jpg.150x150.jpg)
公开(公告)号：US10927116B2
公开(公告)日：2021-02-23
申请号：US15999701
申请日：2018-08-20
发明人： Junli Chen
IPC分类号： C07D487/04
摘要： The present invention relates to a process for synthesizing a compound of formula (I), R1 is phenyl, which is unsubstituted or substituted with one, two or three substituents independently selected from halogen and C1-6alkyl; R2 is C1-6alkyl; R3 is —CxH2x—; x is 1, 2, 3, 4, 5, 6 or 7; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.
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公开(公告)号：US10035804B2
公开(公告)日：2018-07-31
申请号：US15479701
申请日：2017-04-05
发明人： Johannes Aebi , Kurt E. Amrein , Junli Chen , Benoit Hornsperger , Bernd Kuhn , Yongfu Liu , Dongbo Li , Hans Peter Maerki , Rainer E. Martin , Alexander Mayweg , Xuefei Tan , Jun Wu , Jianhua Yu
IPC分类号： C07D487/10 , C07D471/10
CPC分类号： C07D487/10 , A61K9/2054 , A61K9/2059 , C07D471/10 , C07D519/00
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R5, A1, A2, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.
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![Process for the preparation of N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxo-3,5-dihydro-1,4-benzothiazepin-4-yl)-6-methyl-quinazolin-4-amine](/abs-image/US/2018/06/26/US10005770B2/abs.jpg.150x150.jpg)
公开(公告)号：US10005770B2
公开(公告)日：2018-06-26
申请号：US15216501
申请日：2016-07-21
发明人： Junli Chen , Yi Ren , Jin She , Lin Wang , Jianhua Yu , Guocai Zhang
IPC分类号： C07D417/14 , C07D305/06 , C07D305/08
摘要： The present invention relates to a novel process for the preparation of a compound of the formula (I): and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.
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