An integrated circuit for driving a display panel and an anti-interference method are provided. The integrated circuit can include a source driving circuit and an anti-interference circuit. The source driving circuit includes a receiving circuit configured to receive an input signal including image data and process the input signal based on at least one operation parameter to generate output data. The anti-interference circuit is coupled to the receiving circuit. The anti-interference circuit can determine whether an interference event occurs to the input signal based on the input signal or the output data to obtain a determination result and determines whether to adjust the at least one operation parameter of the receiving circuit according to the determination result.