A computerized system and method for planning a medical treatment for an individual under specific medical condition comprises a data input utility configured for receiving input data, and a data processor. The input data includes first input data comprising medical data of a specific individual, and second input data comprising data indicative of at least one endpoint of treatment. The data processor is configured for utilizing the medical data of the specific individual and the data indicative of the at least one endpoint and processing data indicative of disease progression models, each disease progression model corresponding to a treatment plan comprising one or more predetermined treatment protocols for treating the specific medical condition. The data processor generates output data indicative of a treatment effect on the individual with respect to each of the treatment plans and at least one endpoint to evaluate the treatment plans.