A signal amplifier circuit having high power supply rejection ratio includes: a pre-amplifier which generates a driving signal at a driving control node; and a driving circuit which converts an input power to an output power. The driving circuit includes: a driving transistor, having a first terminal coupled to the input power and a second terminal coupled to the output power; and a power rejection circuit which includes a noise selection circuit. When the driving transistor operates in its linear region, the power rejection circuit senses an AC component of a power noise of the input power to generate an operation noise signal. The power rejection circuit generates the power rejection signal in AC form according to the operation noise signal to reject the power noise so as to increase the power supply rejection ratio.