Invention Grant
- Patent Title: 3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor
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Application No.: US16621959Application Date: 2018-06-22
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Publication No.: US11149036B2Publication Date: 2021-10-19
- Inventor: John J. Acton, III , Jianming Bao , Qiaolin Deng , Melissa Egbertson , Ronald Ferguson, II , Xiaolei Gao , Scott Timothy Harrison , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Zhaoyang Meng , Meng Na , Michael T. Rudd , Oleg Selyutin , David M. Tellers , Ling Tong , Fengqi Zhang
- Applicant: John J. Acton, III , Merck Sharp & Dohme Corp. , MSD R&D (China) Co., Ltd. , Jianming Bao , Qiaolin Deng , Melissa Egbertson , Ronald Ferguson, II , Xiaolei Gao , Scott Timothy Harrison , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Zhaoyang Meng , Meng Na , Michael T. Rudd , Oleg Selyutin , David M. Tellers , Ling Tong , Fengqi Zhang
- Applicant Address: US NJ Bridgewater; US NJ Rahway; CN Shanghai; US CA San Mateo; US NJ Princeton; US PA Ambler; US NJ Scotch Plains; US NJ Bridgewater; US PA Elkins Park; US NJ Princeton; CN Shanghai; US NJ Bedminster; US NJ Stewartsville; US PA Ambler; CN Shanghai; US PA Collegeville; US NJ West Windsor; US PA Lansdale; US NJ Warren; US NJ Edison
- Assignee: John J. Acton, III,Merck Sharp & Dohme Corp.,MSD R&D (China) Co., Ltd.,Jianming Bao,Qiaolin Deng,Melissa Egbertson,Ronald Ferguson, II,Xiaolei Gao,Scott Timothy Harrison,Sandra L. Knowles,Chunsing Li,Michael Man-Chu Lo,Robert D. Mazzola, Jr.,Zhaoyang Meng,Meng Na,Michael T. Rudd,Oleg Selyutin,David M. Tellers,Ling Tong,Fengqi Zhang
- Current Assignee: John J. Acton, III,Merck Sharp & Dohme Corp.,MSD R&D (China) Co., Ltd.,Jianming Bao,Qiaolin Deng,Melissa Egbertson,Ronald Ferguson, II,Xiaolei Gao,Scott Timothy Harrison,Sandra L. Knowles,Chunsing Li,Michael Man-Chu Lo,Robert D. Mazzola, Jr.,Zhaoyang Meng,Meng Na,Michael T. Rudd,Oleg Selyutin,David M. Tellers,Ling Tong,Fengqi Zhang
- Current Assignee Address: US NJ Bridgewater; US NJ Rahway; CN Shanghai; US CA San Mateo; US NJ Princeton; US PA Ambler; US NJ Scotch Plains; US NJ Bridgewater; US PA Elkins Park; US NJ Princeton; CN Shanghai; US NJ Bedminster; US NJ Stewartsville; US PA Ambler; CN Shanghai; US PA Collegeville; US NJ West Windsor; US PA Lansdale; US NJ Warren; US NJ Edison
- Agent Eric A. Meade; John C. Todaro
- Priority: WOPCT/CN2017/090384 20170627
- International Application: PCT/US2018/038888 WO 20180622
- International Announcement: WO2019/005587 WO 20190103
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D401/04 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D491/048 ; C07D498/04
Abstract:
The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
Public/Granted literature
- US20200207758A1 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR Public/Granted day:2020-07-02
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