公开(公告)号：US20200207758A1

公开(公告)日：2020-07-02

申请号：US16621959

申请日：2018-06-22

申请人： John J. ACTON, III ,  Jianming BAO ,  Qiaolin DENG ,  Melissa EGBERTSON ,  Ronald FERGUSON, II ,  Xiaolei GAO ,  Scott Timothy HARRISON ,  Sandra L. KNOWLES ,  Chunsing LI ,  Michael Man-Chu LO ,  Robert D. MAZZOLA, Jr. ,  Zhaoyang MENG ,  Meng NA ,  Michael T. RUDD ,  Oleg SELYUTIN ,  David M. TELLERS ,  Ling TONG ,  Fengqi ZHANG

发明人： John J. ACTON, III ,  Jianming BAO ,  Qiaolin DENG ,  Melissa EGBERTSON ,  Ronald FERGUSON, II ,  Xiaolei GAO ,  Scott Timothy HARRISON ,  Sandra L. KNOWLES ,  Chunsing LI ,  Michael Man-Chu LO ,  Robert D. MAZZOLA, Jr. ,  Zhaoyang MENG ,  Meng NA ,  Michael T. RUDD ,  Oleg SELYUTIN ,  David M. TELLERS ,  Ling TONG ,  Fengqi ZHANG

IPC分类号： C07D471/04 ,  C07D401/14 ,  C07D401/04 ,  C07D413/14 ,  C07D405/14 ,  C07D491/048 ,  C07D498/04

摘要： The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

公开(公告)号：US11149036B2

公开(公告)日：2021-10-19

申请号：US16621959

申请日：2018-06-22

申请人： John J. Acton, III ,  Merck Sharp & Dohme Corp. ,  MSD R&D (China) Co., Ltd. ,  Jianming Bao ,  Qiaolin Deng ,  Melissa Egbertson ,  Ronald Ferguson, II ,  Xiaolei Gao ,  Scott Timothy Harrison ,  Sandra L. Knowles ,  Chunsing Li ,  Michael Man-Chu Lo ,  Robert D. Mazzola, Jr. ,  Zhaoyang Meng ,  Meng Na ,  Michael T. Rudd ,  Oleg Selyutin ,  David M. Tellers ,  Ling Tong ,  Fengqi Zhang

发明人： John J. Acton, III ,  Jianming Bao ,  Qiaolin Deng ,  Melissa Egbertson ,  Ronald Ferguson, II ,  Xiaolei Gao ,  Scott Timothy Harrison ,  Sandra L. Knowles ,  Chunsing Li ,  Michael Man-Chu Lo ,  Robert D. Mazzola, Jr. ,  Zhaoyang Meng ,  Meng Na ,  Michael T. Rudd ,  Oleg Selyutin ,  David M. Tellers ,  Ling Tong ,  Fengqi Zhang

IPC分类号： C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D491/048 ,  C07D498/04

摘要： The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.