A cable release system configured to actuate a latch mechanism includes a cable arrangement configured to shift in response to an actuation force. The shifting of the cable arrangement is thereby configured to actuate the latch mechanism. The cable release system also includes a lockout mechanism configured to selectively impede shifting of the cable arrangement in response to the actuation force. Such selective impeding of the shifting of the cable arrangement is thereby configured to prevent actuation of the latch mechanism. A vehicle may employ the cable release system configured to actuate a latch mechanism to thereby unlatch a panel from the vehicle body.