- 专利标题： Heterocyclic lipoxin analogs and uses thereof
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申请号： US16326453申请日： 2017-08-18
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公开(公告)号： US11161824B2公开(公告)日： 2021-11-02
- 发明人: Patrick Guiry , Catherine Godson , Monica De Gaetano , Eibhlin Butler , Claire Wilson , Catherine Tighe , Denise Moran , Andrea Zanetti , Kevin Gahan
- 申请人： University College Dublin, National University of Ireland, Dublin
- 申请人地址： IE Dublin
- 专利权人： University College Dublin, National University of Ireland, Dublin
- 当前专利权人： University College Dublin, National University of Ireland, Dublin
- 当前专利权人地址： IE Dublin
- 代理机构： Hoffman Warnick LLC
- 优先权： GB1614224 20160819
- 国际申请： PCT/EP2017/070979 WO 20170818
- 国际公布： WO2018/033642 WO 20180222
- 主分类号： C07D239/26
- IPC分类号： C07D239/26 ; C07D215/14 ; C07D217/02 ; C07D239/74 ; C07D241/42 ; C07D231/12 ; C07D307/36 ; C07D307/79 ; C07D333/06 ; A61K31/341 ; A61K31/343 ; A61K31/381 ; A61K31/40 ; A61K31/404 ; A61K31/47 ; A61K31/472 ; A61P11/06 ; A61P13/12 ; C07D215/18 ; C07D217/22 ; C07D233/68 ; C07D263/32 ; C07D263/34 ; C07D307/80 ; C07D333/56 ; C07D405/06 ; C07D407/06 ; C07D409/06 ; C07D413/06
摘要：
The present invention relates to a compound of formula (I): wherein L is an optionally substituted heterocyclic group excluding unsubstituted monocyclic pyridine groups; wherein a is 0, 1 or 2; wherein R1 is H or with R2 is a bond; wherein R2 is an optionally substituted alkoxy or aryloxy group, or with R1 forms a bond; wherein R3 is an optionally substituted alkyl group; and wherein R4 is CH2, CMe2 or O. Such compounds may be used in the treatment or prophylaxis of a disease or condition in which inhibition of acute inflammation and/or promotion of its resolution and/or suppression of fibrosis.
公开/授权文献
- US20210053927A1 Heterocyclic Lipoxin Analogs and Uses Thereof 公开/授权日：2021-02-25
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