![Cyclic substituted imidazo[4,5-c]quinoline derivatives](/docs/US/2021-11-02/US11161844B2/abs.jpg.600x600.jpg)
- 专利标题： Cyclic substituted imidazo[4,5-c]quinoline derivatives
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申请号： US16492554申请日： 2018-03-01
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公开(公告)号： US11161844B2公开(公告)日： 2021-11-02
- 发明人: Thomas Allen Chappie , Paul Galatsis , Michelle Renee Garnsey , Christopher John Helal , Jaclyn Louise Henderson , Bethany Lyn Kormos , Ravi G. Kurumbail , Luis Angel Martinez-Alsina , Martin Youngjin Pettersson , Antonia Friederike Stepan , Travis T. Wager
- 申请人： Pfizer Inc.
- 申请人地址： US NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： US NY New York
- 代理机构： Haley Guiliano LLP
- 代理商 James F. Haley, Jr.
- 国际申请： PCT/IB2018/051318 WO 20180301
- 国际公布： WO2018/163030 WO 20180913
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D471/14
![Cyclic substituted imidazo[4,5-c]quinoline derivatives](/abs-image/US/2021/11/02/US11161844B2/abs.jpg.150x150.jpg)
摘要：
The present invention provides novel cyclic substituted imidazo[4,5-c]quinoline derivatives of Formula (I), and the pharmaceutically acceptable salts thereof; wherein R1, R2, R4, R5, R6, X and Z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.
公开/授权文献
- US20200039977A1 CYCLIC SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE DERIVATIVES 公开/授权日：2020-02-06
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